Moderate Diet

Omega3 Repletion

Summary

EPA-led omega-3 supplementation corrects a genuine modern-diet deficiency (seed-oil-dominant eating → omega-6:3 imbalance, low oily-fish intake) — moderate evidence for depression at an EPA-dominant dose and for raising a low Omega-3 Index; but it is NULL for cardiovascular prevention in already-replete people (VITAL / ASCEND / STRENGTH / OMEMI), so it is a repletion lever, never cardioprotection. ---

MODERATE for the EPA-led mood / index-restoration use (replicated meta-analyses, but heterogeneous and dose/EPA-fraction-sensitive); HIGH confidence in the CVD-null finding (four large, well-powered RCTs concordant).Last updated June 2026
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